Lipoproteins, cholesterol and phospholipids in sera of rabbits following ligation of the common bile duct or injection of carbon tetrachloride.

In pediatric practice it was not infrequent to meet with a difficulty in etiological diagnosis for neonatal jaundice. For example, both neonatal hepatitis and atresia of the bile duct would present similar clinical and laboratory findings of "obstructive jaundice", and while an early surgical treatment is recommended for the cases with atresia of the bile duct, the therapy for those of neonatal hepatitis will be quite different. In the present investigation it was tried to investigate whether or not any difference of lipoprotein patterns, cholesterol and phospholipids would be found between rabbits with ligation of the common bile duct, which may be considered as an extreme case of biliary obstruction on one side and those with severe damage on hepatic parenchyma produced by carbon tetrachloride injection on the other.